Water → 8-Methylcoumarin

HRID 389310

반응식

HRID 389310 반응식
[OH:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C.O>CCCCCC>[CH3:10][C:9]1[CH:8]=[CH:7][CH:6]=[C:3]2[C:2]=1[O:1][C:11](=[O:13])[CH:12]=[CH:4]2

참가 물질

6

반응물 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 5227773-Methylsalicylaldehyde

생성물 1

HCID 157348-Methylcoumarin수율 85%

시약·촉매·용매 1

HCID 8058Hexane용매

반응 조건

온도
177.5 °C

실험 절차

The suspension of 2-Hydroxy-3-methyl benzaldehyde (30 gm, 0.220 mole) and anhydrous Sodium acetate (45 gm, 0.55 mole) in Acetic anhydride (45 gm, 0.44 mole) was heated at 175-180° C. for 6 hours. The reaction mixture was cooled; water (150 ml) and Hexane (60 ml) were added. It was stirred for an hour and filtered. The obtained solid was stirred with Diethyl ether (30 ml). Finally the suspension was filtered and dried to give 19 gm desired product.

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. stirringThe obtained solid was stirred with Diethyl ether (30 ml)
  4. filtrationFinally the suspension was filtered
  5. customdried

출처 및 근거

ORD 기록
ord-58d0d4d5d47848f591413a9b1a765b8b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378118B2

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