Methyl iodide → (NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide

HRID 390699

반응식

HRID 390699 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[C:14]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[O:15])=[CH:4][CH:3]=1.[I:21][CH3:22]>C(#N)C>[I-:21].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:12][CH2:11][S:10]/[C:9]/2=[N:13]\[C:14]([N:16]2[CH:20]=[CH:19][N+:18]([CH3:22])=[CH:17]2)=[O:15])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 87449094HCID 87449094, 화합물

생성물 1

HCID 87447829(NZ)-N-[3-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]-3-methylimidazol-3-ium-1-carboxamide iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-[(2Z)-3-(4-Chlorophenyl)-1,3-thiazolidin-2-ylidene]-1H-imidazole-1-carboxamide (320 mg, 1.043 mmol, Example 25A) was suspended in dry acetonitrile (5 mL), and then iodomethane (0.325 mL, 5.22 mmol) was added. The mixture stirred at room temperature. After four days, the solvent was evaporated to give the title product.

후처리

  1. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-9fa71b9d1bd841759cde32862025345d
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383657B2

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