Iodoethane → Tert-butyl 5-bromopyridin-2-YL(ethyl)carbamate

HRID 391079노트

반응식

HRID 391079 반응식
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[H-].[Na+].I[CH2:19][CH3:20]>C1COCC1>[C:4]([O:3][C:1](=[O:2])[N:8]([C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)[CH2:19][CH3:20])([CH3:7])([CH3:6])[CH3:5]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 162178432-(Boc-amino)-5-bromopyridine

생성물 1

HCID 53217453Tert-butyl 5-bromopyridin-2-YL(ethyl)carbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-(BOC-amino)-5-bromopyridine (500 mg) in THF (20 mL) at 0° C. was added sodium hydride (88 mg) and the reaction stirred for 20 min. Then, iodoethane (0.18 mL) was added and the reaction stirred at room temperature for 16 h. The reaction was quenched with water (20 mL) and extracted into ethylacetate (3×20 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-ethyl-carbamic acid tert-butyl ester as a white solid.

후처리

  1. stirringthe reaction stirred at room temperature for 16 h
  2. customThe reaction was quenched with water (20 mL)
  3. extractionextracted into ethylacetate (3×20 mL)
  4. dry with materialThe organic layers were dried (MgSO4)

출처 및 근거

ORD 기록
ord-439df2aa11e04bd2b1c54ff44cb1a47a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

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