Methyl iodide → 2-(N-BOC-N-methylamino)-5-bromopyridine

HRID 391098노트

반응식

HRID 391098 반응식
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[H-].[Na+].I[CH3:19]>C1COCC1>[C:4]([O:3][C:1](=[O:2])[N:8]([C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)[CH3:19])([CH3:7])([CH3:6])[CH3:5]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 162178432-(Boc-amino)-5-bromopyridine

생성물 1

HCID 111969422-(N-BOC-N-methylamino)-5-bromopyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-(BOC-amino)-5-bromopyridine (3.06 g) in THF (50 mL) was added sodium hydride (538 mg) and the reaction stirred at room temperature for 20 min. Then, iodomethane (0.84 mL) was added and the reaction stirred at room temperature for 16 h. The reaction was quenched with water (30 mL) and extracted into dichloromethane (3×30 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-methyl-carbamic acid tert-butyl ester as an oil.

후처리

  1. stirringthe reaction stirred at room temperature for 16 h
  2. customThe reaction was quenched with water (30 mL)
  3. extractionextracted into dichloromethane (3×30 mL)
  4. dry with materialThe organic layers were dried (MgSO4)

출처 및 근거

ORD 기록
ord-066a9c00441346abb9f849f80864cf79
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

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