1-(4-Aminophenyl)-1-propanol → (2e,4e,6e,8e)-3,7-Dimethyl-n-(pyridin-4-yl)-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenamide

HRID 391366

반응식

HRID 391366 반응식
[NH2:1][C:2]1C=C[C:5]([CH:8](O)CC)=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH2:18][CH2:17][CH2:16][C:15]([CH3:20])([CH3:19])[C:14]=1/[CH:21]=[CH:22]/[C:23](/[CH3:33])=[CH:24]/[CH:25]=[CH:26]/[C:27](/[CH3:32])=[CH:28]/[C:29]([OH:31])=O.C(Cl)CCl.C1C=CC2N(O)N=[N:44]C=2C=1>CN(C=O)C>[CH3:32]/[C:27](/[CH:26]=[CH:25]/[CH:24]=[C:23](\[CH3:33])/[CH:22]=[CH:21]/[C:14]1[C:15]([CH3:19])([CH3:20])[CH2:16][CH2:17][CH2:18][C:13]=1[CH3:12])=[CH:28]\[C:29]([NH:44][C:4]1[CH:3]=[CH:2][N:1]=[CH:8][CH:5]=1)=[O:31]

참가 물질

5

반응물 3

HCID 2358751-(4-Aminophenyl)-1-propanolHCID 444795Retinoic AcidHCID 86583742Edc hobt

생성물 1

HCID 59539418(2e,4e,6e,8e)-3,7-Dimethyl-n-(pyridin-4-yl)-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Coupling of (4-amino)phenylpropanol (453 mg; 3 mmol) and retinoic acid (600 mg, 2 mmol) in anhydrous DMF (4 mL) using standard EDC/HOBt coupling condtions yielded the desired amide as a pale, yellow solid (600 mg, 69%). EMS m/z: 434 ([M+1]+).

출처 및 근거

ORD 기록
ord-a39325d79a5a4919aba96709be717534
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383836B2

연결된 노트

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