(3-Bromo-5-nitrophenyl)methanol → (3-Amino-5-bromophenyl)methanol

HRID 391429

반응식

HRID 391429 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][OH:12])[CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>CO.[Pt](=O)=O>[NH2:8][C:6]1[CH:5]=[C:4]([CH2:11][OH:12])[CH:3]=[C:2]([Br:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 14866972(3-Bromo-5-nitrophenyl)methanol

생성물 1

HCID 58993589(3-Amino-5-bromophenyl)methanol

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

(3-Bromo-5-nitrophenyl)methanol (3.9 g, 16.8 mmol) in methanol (35 mL) was flushed with nitrogen, and treated with platinum (IV) oxide (390 mg). The flask was flushed with hydrogen and allowed to stir under an atmosphere of hydrogen for 1 h. The reaction was flushed with nitrogen, filtered through celite, and concentrated to afford 3.1 g (94%). 1H-NMR (CDCl3, 300 MHz) δ 6.95 (s, 1H), 6.80 (s, 1H), 6.79 (s, 1H), 4.61 (s, 2H). Mass spec.: 203.96 (MH)+.

후처리

  1. customThe flask was flushed with hydrogen
  2. customThe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated
  5. customto afford 3.1 g (94%)

출처 및 근거

ORD 기록
ord-e4f63e5b3b20495b971be59e1fb5bc9b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383821B2

연결된 노트

불러오는 중…