Hydrochloric Acid → N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

HRID 394456

반응식

HRID 394456 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([N:10]1[CH2:19][CH2:18][C:17]2[C:12](=[CH:13][C:14]([S:20](Cl)(=[O:22])=[O:21])=[CH:15][CH:16]=2)[CH2:11]1)(=[O:9])[CH3:8].C(NC(C)C)(C)C.Cl.N1(S(C2C=C3C(CCNC3)=CC=2)(=O)=O)CCOCC1>C1COCC1>[C:7]([N:10]1[CH2:19][CH2:18][C:17]2[C:12](=[CH:13][C:14]([S:20]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)(=[O:21])=[O:22])=[CH:15][CH:16]=2)[CH2:11]1)(=[O:9])[CH3:8]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 7912DiisopropylamineHCID 8083MorpholineHCID 126069042-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chlorideHCID 219836637-(Morpholine-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 18176496N-Acetyl-7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

was obtained as described in Example 4A by reacting morpholine with 2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride in the presence of diisopropylamine in THF and by heating with 50% concentrated hydrochloric acid and, after alkaline workup, converted into the corresponding 7-(morpholin-4-ylsulfonyl)-1,2,3,4-tetrahydroisoquinoline.

후처리

  1. customwas obtained

출처 및 근거

ORD 기록
ord-4465e0f4aed34412858468b27119c327
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06602867B1

연결된 노트

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