Water → HCID 16102059, 화합물

HRID 395333

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HRID 395333 반응식
F[C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([C:8]#[N:9])[CH:7]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C.O>CN1C(=O)CCC1>[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([C:2]2[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([C:8]#[N:9])[CH:7]=2)[CH2:16][CH2:15]1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 37564675-Fluoro-2-nitrobenzonitrile

생성물 1

HCID 16102059HCID 16102059, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
100 °C

실험 절차

5-Fluoro-2-nitrobenzenecarbonitrile (1.02 eq) and N-methylpiperazine, (1.0 eq) were dissolved in NMP. Triethylamine (2.1 eq) was added, and the resulting solution heated at 100° C. for 1 hour. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a green solid. LC/MS m/z 247.3 (MH+), Rf 1.46 minutes.

후처리

  1. temperatureThe solution was cooled to room temperature
  2. customA precipitate formed which
  3. filtrationwas filtered

출처 및 근거

ORD 기록
ord-53df55582943408cafa0c461ad6b6887
출처 데이터셋
uspto-grants-2003_08
특허 번호
US06605617B2

연결된 노트

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