Hydrochloric Acid → isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

HRID 3978

반응식

HRID 3978 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.Cl>C(O)C(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([O:16][CH2:4][CH:5]([CH3:10])[CH3:6])=[O:15])[CH:7]=[CH:6]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 156391Naproxen

생성물 1

HCID 54469957isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

시약·촉매·용매 1

HCID 6560Isobutanol용매

실험 절차

A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.

후처리

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue is purified by chromatography

출처 및 근거

ORD 기록
ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723033

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