Hydrochloric Acid → isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=[CH:6]2.Cl>C(O)C(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([O:16][CH2:4][CH:5]([CH3:10])[CH3:6])=[O:15])[CH:7]=[CH:6]2참가 물질
4
실험 절차
A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.
후처리
- distillationthe excess alcohol is distilled off in vacuo
- customthe residue is purified by chromatography
출처 및 근거
- ORD 기록
- ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a
- 출처 데이터셋
- uspto-grants-1988_02
- 특허 번호
- US04723033
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