Phenol → Di-tert-butyl ether

HRID 398022

반응식

[C:1]1([OH:7])[CH:6]=CC=C[CH:2]=1.CNC(=NC)O[C:12]([CH3:15])([CH3:14])[CH3:13].[C:18](OCC)(=O)C.CCCCCC>>[C:12]([O:7][C:1]([CH3:2])([CH3:6])[CH3:18])([CH3:15])([CH3:14])[CH3:13]

참가 물질

반응물 3

HCID 996Phenol

HCID 21226206Ethyl acetate hexane

HCID 23001675N,N'-dimethyl-O-t-butylisourea

생성물 1

HCID 22541Di-tert-butyl ether수율 15%

실험 절차

Following a procedure analogous to (3b), the phenol from (3a) (270 mg, 0.97 mmol) was reacted with N,N′-dimethyl-O-t-butylisourea. Silica gel chromatography (ethyl acetate-hexane, 20:80) gave the t-butyl ether (50.2 mg, 15%) as a 1:1 mixture of two isomers. MS found: (M+H)+=334.

출처 및 근거

ORD 기록: ord-06a1d31e4388451ab0e3ab6eef91a634
출처 데이터셋: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06610731B2

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