4,6-Dichloro-2-methyl-5-nitropyrimidine → 4,6-Dichloro-2-methylpyrimidin-5-amine

HRID 398723

반응식

HRID 398723 반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([Cl:11])[N:5]=[C:4]([CH3:12])[N:3]=1>C1(C)C=CC=CC=1.[Ni]>[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([Cl:11])[N:5]=[C:4]([CH3:12])[N:3]=1

참가 물질

4

반응물 1

HCID 831924,6-Dichloro-2-methyl-5-nitropyrimidine

생성물 1

HCID 7366744,6-Dichloro-2-methylpyrimidin-5-amine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 1140Toluene용매

실험 절차

The third intermediate, 4,6-dichloro-2-methyl-5-nitropyrimidine is hydrogenated over Raney-Ni as a 10% to 30% solution in toluene to afford the corresponding compound, 4,6-dichloro-2-methyl-5-aminopyrimidine, as a fourth intermediate.

출처 및 근거

ORD 기록
ord-b8efa4f6156f4b12be49de0edf7b530d
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05816260

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