Diethyl Carbonate → 4-Ethyl-4-hydroxymethyl-2-oxazolidinone

HRID 398813

반응식

HRID 398813 반응식
[NH2:1][C:2]([CH2:7][CH3:8])([CH2:5][OH:6])[CH2:3][OH:4].[C:9](=O)(OCC)[O:10]CC>C[O-].[Na+].CCO>[CH2:7]([C:2]1([CH2:5][OH:6])[CH2:3][O:4][C:9](=[O:10])[NH:1]1)[CH3:8]

참가 물질

5

반응물 2

HCID 7766Diethyl CarbonateHCID 82822-Amino-2-ethyl-1,3-propanediol

생성물 1

HCID 112635594-Ethyl-4-hydroxymethyl-2-oxazolidinone수율 66.5%

시약·촉매·용매 2

HCID 10942334Sodium Methoxide촉매HCID 702Ethanol용매

실험 절차

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol(100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone(200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

후처리

  1. customwas collected
  2. temperatureThe reaction mixture was cooled
  3. additionadded acetone(200 ml)
  4. customto stand overnite at room temperature
  5. filtrationThe resulting suspension was filtered

출처 및 근거

ORD 기록
ord-58e4b581318740f5b42cfeb857ddca99
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05817652

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