Hydrochloric Acid → 3-(2-Benzyloxycarbonylpyrrol-1-yl)benzoic acid

HRID 399820노트

반응식

HRID 399820 반응식
[OH-].[Na+].[CH2:3]([O:10][C:11]([C:13]1[N:14]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23]C)=[O:22])[CH:15]=[CH:16][CH:17]=1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O1CCOCC1.Cl>O.C(OCC)(=O)C>[CH2:3]([O:10][C:11]([C:13]1[N:14]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([OH:23])=[O:22])[CH:15]=[CH:16][CH:17]=1)=[O:12])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 18945465Methyl 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoate

생성물 1

HCID 189453413-(2-Benzyloxycarbonylpyrrol-1-yl)benzoic acid수율 50.1%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

1N-Sodium hydroxide solution (1.5 ml) was added to a mixture of methyl 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoate (0.5 g) and dioxane (20 ml), and the mixture was stirred for 3 days at ambient temperature. The reaction mixture was poured into the mixture of ethyl acetate and water and the separated aqueous layer was adjusted to pH 1 with 6N-hydrochloric acid. The mixture was extracted with ethyl acetate and extract was washed with brine and dried over magnesium sulfate. The solvent was removed by concentration and the residue was triturated with n-hexane to give 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoic acid (0.24 g).

후처리

  1. extractionThe mixture was extracted with ethyl acetate
  2. extractionextract
  3. washwas washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was removed by concentration
  6. customthe residue was triturated with n-hexane

출처 및 근거

ORD 기록
ord-e86ac1fc5fd84afd8327dc1ea33c1f1d
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824691

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