Azobisisobutyronitrile → 1,3-Dibromo-5-(bromomethyl)-2-chlorobenzene

HRID 402825노트

반응식

HRID 402825 반응식
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([Br:9])[C:3]=1[Cl:10].C1C(=O)N([Br:18])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>>[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][Br:18])[CH:5]=[C:4]([Br:9])[C:3]=1[Cl:10]

참가 물질

4

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 229702894-Chloro-3,5-dibromotoluene

생성물 1

HCID 667653881,3-Dibromo-5-(bromomethyl)-2-chlorobenzene수율 57.9%

실험 절차

To 1,3-dibromo-2-chloro-5-methylbenzene (1000 mg, 3.52 mmol) was added NBS (688 mg, 3.87 mmol) and AIBN (57.7 mg, 0.352 mmol). The mixture was stirred at room temperature for 30 minutes and then heated to 80° C. overnight. The solution was evaporated and the residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes) to provide the title compound (740 mg) as a clear oil.

후처리

  1. temperatureheated to 80° C. overnight
  2. customThe solution was evaporated
  3. customthe residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes)

출처 및 근거

ORD 기록
ord-fdbe0c5583ad4acf86d51d17badb808e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08742110B2

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