Hydrochloric Acid → (S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

HRID 403996노트

반응식

HRID 403996 반응식
[C:1]([C:5]1[CH:37]=[CH:36][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:26]=[C:25]4[C:21]([CH2:22][N:23]([C@@H:28]([CH:33]([CH3:35])[CH3:34])[C:29]([O:31]C)=[O:30])[C:24]4=[O:27])=[CH:20][CH:19]=3)=[N:16][CH:17]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].CO.[Li+].[OH-].Cl>C1COCC1.O>[C:1]([C:5]1[CH:37]=[CH:36][C:8]([C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:26]=[C:25]4[C:21]([CH2:22][N:23]([C@@H:28]([CH:33]([CH3:34])[CH3:35])[C:29]([OH:31])=[O:30])[C:24]4=[O:27])=[CH:20][CH:19]=3)=[N:16][CH:17]=2)=[O:10])=[CH:7][CH:6]=1)([CH3:3])([CH3:2])[CH3:4]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 131731552(S)-Methyl 2-(6-(5-(4-tert-butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

생성물 1

HCID 67306402(S)-2-(6-(5-(4-tert-Butylbenzamido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

The compound of example 403 (80 mg, 0.160 mmol) was taken in THF (4 mL) and MeOH (1 mL) and to this reaction mixture, 1N LiOH (33.59 mg, 0.800 mmol) was added and stirred at room temperature for 2-3 h. After completion of the reaction, the solvent was evaporated and the residue obtained was dissolved in water and acidified with 1 N HCl to obtain the title compound, which was filtered and dried.

후처리

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated
  3. customthe residue obtained

출처 및 근거

ORD 기록
ord-278223d8cd3c4f4db5d3b7849f084706
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748426B2

반응 노트

불러오는 중…