Hydrochloric Acid → 4-(4-Isopropoxyphenoxy)benzaldehyde oxime

HRID 404880노트

반응식

HRID 404880 반응식
[CH:1]([O:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].Cl.[NH2:21][OH:22].Cl>N1C=CC=CC=1>[CH:1]([O:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][C:10]2[CH:17]=[CH:16][C:13]([CH:14]=[N:21][OH:22])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 443297Hydroxyamine hydrochlorideHCID 877217474-(4-Isopropoxyphenoxy)benzaldehyde

생성물 1

HCID 1317316044-(4-Isopropoxyphenoxy)benzaldehyde oxime수율 98.1%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of Example 17B (1.42 g, 5.56 mmol) in pyridine (10 mL) was added hydroxylamine hydrochloride (3.30 g, 47.5 mmol). The mixture was heated to reflux with a heat gun. After cooling, the mixture was poured into 10% HCl. The precipitates were collected and washed with 10% HCl followed by water, and then dried under vacuum at 50° C. overnight to give the desired product as a white solid (1.48 g, 98%).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux with a heat gun
  3. temperatureAfter cooling
  4. customThe precipitates were collected
  5. washwashed with 10% HCl
  6. customdried under vacuum at 50° C. overnight

출처 및 근거

ORD 기록
ord-4b232765ea46416e8453971f91e488c7
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748627B2

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