Hydrochloric Acid → 1-(2-Bromo-4-chlorophenyl)ethanol

HRID 405234노트

반응식

HRID 405234 반응식
[BH4-].[Na+].C1COCC1.[Br:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16](=[O:18])[CH3:17].Cl>CO>[Br:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[CH:16]([OH:18])[CH3:17]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 47126441-(2-Bromo-4-chlorophenyl)ethanone

생성물 1

HCID 574450731-(2-Bromo-4-chlorophenyl)ethanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Solid NaBH4 (354 mg, 9.4 mmol) was added to a 0° C., THF (5 mL) and MeOH (15 mL) solution of 1-(2-bromo-4-chlorophenyl)ethanone (1.8 g, 7.8 mmol). After 30 min 2N aqueous HCl was slowly added, and the resulting mixture was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

후처리

  1. extractionthe resulting mixture was extracted with EtOAc
  2. dry with materialThe combined organic extracts were dried (Na2SO4)
  3. concentrationconcentrated
  4. custompurified via column chromatography

출처 및 근거

ORD 기록
ord-de0ade1835f8404786d55c3e197ec22f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08748624B2

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