Benzo(F)Quinoline → Mls002703342

HRID 405651

반응식

HRID 405651 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C(Cl)Cl.[CH:14]1[C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]=[CH:16][CH:15]=1.[C-:28]#[N:29].[K+]>C(Cl)Cl.O>[C:28]([CH:16]1[CH:15]=[CH:14][C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[CH:20]=[CH:19][C:18]=2[N:17]1[C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)#[N:29]

참가 물질

7

반응물 4

HCID 6796Benzo(F)QuinolineHCID 7412Benzoyl chlorideHCID 9032Potassium CyanideHCID 21908982Water methylene chloride

생성물 1

HCID 262649Mls002703342

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

648 μl (5.58 mmol) benzoyl chloride was added to a two phase system of water/methylene chloride over a period of two hours. These two layers contain 500 mg (2.79 mmol) of benzo(f)chinolin in the methylene chloride layer and 545 mg (8.37 mmol) KCN in water. Stirring was continued for 6 hours. The organic phase was separated and washed with water, 5% hydrochloric acid, water, 5% NaOH solution, and again with water. After drying over magnesium sulfate, the solution was evaporated to dryness.

후처리

  1. customThe organic phase was separated
  2. washwashed with water, 5% hydrochloric acid, water, 5% NaOH solution
  3. dry with materialAfter drying over magnesium sulfate
  4. customthe solution was evaporated to dryness

출처 및 근거

ORD 기록
ord-efdf6f83041f43f2a404661c530990f1
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08753641B2

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