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Methanol → 1-Benzo[b]thiophen-3-yl-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-1-ol

HRID 40643
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인쇄 미리보기

반응식

HRID 40643 반응식
[S:1]1[CH:5]=[C:4]([C:6](=[O:29])[CH2:7][CH2:8][N:9]2[CH2:16][CH:15]3[N:17]([C:19]4[CH:28]=[CH:27][C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH:20]=4)[CH2:18][CH:10]2[CH2:11][CH:12]=[CH:13][CH2:14]3)[C:3]2[CH:30]=[CH:31][CH:32]=[CH:33][C:2]1=2.[BH4-].[Na+].CO.[OH-].[Na+]>C(OCC)(=O)C>[S:1]1[CH:5]=[C:4]([CH:6]([OH:29])[CH2:7][CH2:8][N:9]2[CH2:16][CH:15]3[N:17]([C:19]4[CH:28]=[CH:27][C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[CH:20]=4)[CH2:18][CH:10]2[CH2:11][CH:12]=[CH:13][CH2:14]3)[C:3]2[CH:30]=[CH:31][CH:32]=[CH:33][C:2]1=2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 887MethanolHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 692332961-Benzo[b]thiophen-3-yl-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-1-one

생성물 1

HCID 692325911-Benzo[b]thiophen-3-yl-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-1-ol

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매

실험 절차

1-Benzo[b]thiophen-3-yl-3-(9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-1-one (8 mg, 0.0176 mmol), sodium borohydride (20 mg, 0.5 mmol) and methanol (1 ml), were placed in a round bottom flask and the reaction mixture stirred for one hour at room temperature. To the reaction mixture were then added a solution of 1N NaOH (10 mL) and ethyl acetate (10 mL). The resulting mixture was separated and the organic layer was dried with magnesium sulfate, filtered and evaporated under reduced pressure to yield the title compound as a solid.

후처리

  1. customThe resulting mixture was separated
  2. dry with materialthe organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-756743c2e16a4c14abaed361ee564104
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08530475B2

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