Benzylamine → N-Benzyl-2,2-dimethoxyethan-1-amine

HRID 406934

반응식

HRID 406934 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][O:10][CH:11]([O:14][CH3:15])[CH2:12]Cl.[OH-].[Na+]>O>[CH2:1]([NH:8][CH2:12][CH:11]([O:14][CH3:15])[O:10][CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7504BenzylamineHCID 14798Sodium HydroxideHCID 609862-Chloro-1,1-dimethoxyethane

생성물 1

HCID 276572N-Benzyl-2,2-dimethoxyethan-1-amine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
27.5 °C

실험 절차

Benzylamine (0.927 kg), chloroacetaldehydedimethylacetal (0.909 kg), sodium hydroxide solution (0.35 kg) in 2.72 L of water were charged into the flask under stirring at 25-30° C. for 10-15 min. Reaction mass was heated to 100-102° C. under stirring for 30 hrs. After completion of reaction, reaction mass was allowed to settle for 30 min. Two layers are separated and upper product layer was collected, distilled under high vacuum.

후처리

  1. customReaction mass
  2. temperaturewas heated to 100-102° C.
  3. stirringunder stirring for 30 hrs
  4. customAfter completion of reaction, reaction mass
  5. waitto settle for 30 min
  6. customTwo layers are separated
  7. customupper product layer was collected
  8. distillationdistilled under high vacuum

출처 및 근거

ORD 기록
ord-90d4d3a682834183b60fa6376a558089
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754215B2

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