Cesium carbonate → tert-butyl (3S,5R)-1-(3-(2-(2,6-difluorophenyl)-quinazolin-8-ylamino)pyridin-4-yl)-5-methylpiperidin-3-ylcarbamate

반응식

[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][C@H:12]([CH3:14])[CH2:11][C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]1.FC(F)(F)S(O[C:29]1[CH:30]=[CH:31][CH:32]=[C:33]2[C:38]=1[N:37]=[C:36]([C:39]1[C:44]([F:45])=[CH:43][CH:42]=[CH:41][C:40]=1[F:46])[N:35]=[CH:34]2)(=O)=O.C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.C(OCC)(=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:45][C:44]1[CH:43]=[CH:42][CH:41]=[C:40]([F:46])[C:39]=1[C:36]1[N:35]=[CH:34][C:33]2[C:38](=[C:29]([NH:1][C:2]3[CH:3]=[N:4][CH:5]=[CH:6][C:7]=3[N:8]3[CH2:13][C@H:12]([CH3:14])[CH2:11][C@H:10]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH2:9]3)[CH:30]=[CH:31][CH:32]=2)[N:37]=1