Sodium Chloride → 2-(2-Methoxyphenyl)acetaldehyde

HRID 408492

반응식

HRID 408492 반응식
S(=O)(=O)=O.[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][OH:15].C(N(CC)CC)C.[Cl-].[Na+]>CS(C)=O.ClCCl>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH:14]=[O:15]

참가 물질

7

반응물 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 24682Sulfur trioxideHCID 819092-Methoxyphenethyl alcohol

생성물 1

HCID 2695482-(2-Methoxyphenyl)acetaldehyde수율 86%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 6344Dichloromethane용매

실험 절차

A solution of pyridine complex with sulfur trioxide (134 g, 0.842 mol) in dimethylsulfoxide (150 mL) was slowly added to a solution of 2-(2-methoxy-phenyl)-ethanol (43 g, 0.28 mol) and triethylamine (86 g, 0.85 mol) in dichloromethane (500 mL) at 0° C. After being stirred 30 min, the mixture was poured into a saturated aqueous solution of sodium chloride and the organic layer was washed with dilute hydrochloric acid, a saturated aqueous solution of sodium chloride, dried over sodium sulfate and evaporated to dryness to give (2-methoxy-phenyl)-acetaldehyde (36 g, 0.24 mol, 86%) which was used in the next step directly.

후처리

  1. washthe organic layer was washed with dilute hydrochloric acid
  2. dry with materiala saturated aqueous solution of sodium chloride, dried over sodium sulfate
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-74a84c87c09243949b11f5548591bc27
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759335B2

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