Hydrochloric Acid → (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate

HRID 408996

반응식

HRID 408996 반응식
[ClH:1].[NH2:2][C@@H:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([O:6][CH3:7])=[O:5].[P:14](Cl)(Cl)(=[O:26])[O:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1>C(Cl)Cl>[Cl:1][C:17]1[CH:18]=[CH:19][C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:16]=1[O:15][P:14](=[N:2][C@@H:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([O:6][CH3:7])=[O:5])=[O:26]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 5756311-DichlorophosphoryloxynaphthaleneHCID 1201451Methyl phenylglycinate, L-

생성물 1

HCID 66779381(2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the HCl salt of (S)-methyl 2-amino-2-phenylacetate (2 g), naphthalen-1-yl phosphorodichloridate (2.59 g), TEA (2.76 mL) and DCM (60 mL) were combined to give (2S)-methyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate as a pale yellow thick oil. The crude compound was taken forward without further purification.

후처리

  1. customfor synthesizing naphthyl (aminoacid ester) phosphorochloridates

출처 및 근거

ORD 기록
ord-1263948a19004717ad6165216af6756f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759318B2

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