Chlorotrimethylsilane → ((1,1-Dimethyl-2-propynyl)oxy)trimethylsilane

HRID 410438노트

반응식

HRID 410438 반응식
[CH3:1][C:2]([OH:6])([C:4]#[CH:5])[CH3:3].CCN(CC)CC.[Si:14](Cl)([CH3:17])([CH3:16])[CH3:15]>CN(C1C=CN=CC=1)C>[CH3:15][Si:14]([CH3:17])([CH3:16])[O:6][C:2]([CH3:3])([C:4]#[CH:5])[CH3:1]

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 82582-Methyl-3-butyn-2-olHCID 8471Triethylamine

생성물 1

HCID 87344((1,1-Dimethyl-2-propynyl)oxy)trimethylsilane수율 57.5%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

To a solution of 2-methylbut-3-yn-2-ol (140 g, 1.67 mol) was added DMAP (20 g 0.17 mol), Et3N (927 ml, 3.33 mol) and TMS-Cl (289 g, 2.66 mol) at 5 degree under a nitrogen atmosphere. After being stirred one hour, the mixture was washed with water, dried (MgSO4), filtered, concentrated, and distilled to obtain trimethyl[(2-methylbut-3-yn-2-yl)oxy]silane (150 g, 0.96 mol).

후처리

  1. washthe mixture was washed with water
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-b49f4e4b7bc34026b242b9757d4ecda6
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759366B2

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