N-(2-Chloroethyl)dibenzylamine → HCID 67332450, 화합물

HRID 410988

반응식

HRID 410988 반응식
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([O:23][C:24](=[O:30])[N:25]([CH2:27][CH2:28][OH:29])[CH3:26])([CH3:22])([CH3:21])[CH3:20].[OH-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O1CCOCC1>[C:19]([O:23][C:24](=[O:30])[N:25]([CH2:27][CH2:28][O:29][CH2:10][CH2:9][N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:26])([CH3:22])([CH3:20])[CH3:21]

참가 물질

6

반응물 3

HCID 5820N-(2-Chloroethyl)dibenzylamineHCID 14797Potassium HydroxideHCID 545700N-(tert-Butoxycarbonyl)-N-methyl-2-aminoethanol

생성물 1

HCID 67332450HCID 67332450, 화합물수율 32.6%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 312751,4-Dioxane용매

실험 절차

[2-(2-Dibenzylamino-ethoxy)-ethyl]-methyl-carbamic acid tert-butyl ester (200 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (400 mg), (2-hydroxy-ethyl)-methyl-carbamic acid tert-butyl ester (525 mg), 50% (w/w) KOH solution (1.8 mL) and tetrabutylammonium bromide (57.7 mg) in dioxane (1.8 mL).

출처 및 근거

ORD 기록
ord-843280e7221d4553b5e61ad4043f6770
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

연결된 노트

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