1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 411156

반응식

HRID 411156 반응식
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

생성물 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine수율 65%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

후처리

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

출처 및 근거

ORD 기록
ord-0b8309128be54490ac5ad24413da23b1
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559143B1

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