Methanol → methyl (2S)-4-methyl-2-(methylamino)pentanoate

HRID 412110

반응식

HRID 412110 반응식
[CH3:1][NH:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].O1CCOC[CH2:12]1.CO>Cl>[CH3:12][O:9][C:8](=[O:10])[C@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[NH:2][CH3:1]

참가 물질

5

반응물 3

HCID 887MethanolHCID 312751,4-DioxaneHCID 2777993N-Methylleucine

생성물 1

HCID 10921446methyl (2S)-4-methyl-2-(methylamino)pentanoate수율 100%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

N-methyl-L-leucine (1.3 g, 8.95 mmol) was dissolved in 4M HCl, 1,4-dioxane (10 mL) and methanol (10 mL). The solution was stirred overnight at room temperature, then concentrated to afford the title compound as a white solid (100%). MS (ESI): 160.0 (M+H)+.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-873da0f5b55f479496f9ff147aa8e0df
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562842B2

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