Hydrochloric Acid → 4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

HRID 412528노트

반응식

HRID 412528 반응식
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][C:16]3([C:28]([OH:30])=[O:29])[CH2:21][CH2:20][N:19]([C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)[CH2:18][CH2:17]3)=[CH:9][CH:10]=2)[CH2:5]1)(=[NH:3])[NH2:2].[ClH:31].[OH-].[Na+]>O>[ClH:31].[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][C:16]3([C:28]([OH:30])=[O:29])[CH2:17][CH2:18][N:19]([C:22]4[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=4)[CH2:20][CH2:21]3)=[CH:9][CH:10]=2)[CH2:5]1)(=[NH:2])[NH2:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 14798Sodium HydroxideHCID 9844392JTV-803 free base

생성물 1

HCID 696972654-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

4-(2-Amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(pyridin-4-yl)piperidine-4-carboxylic acid (7.55 g) was suspended in water (135 ml) and 1N hydrochloric acid (20 ml) was added. The mixture was heated to 60° C. and thereto was successively added dropwise 1N aqueous sodium hydroxide solution (2.9 ml) and 1N hydrochloric acid (1 ml). The mixture was stood at room temperature for 12 hours and the resultant crystals were collected by filtration, washed with water and dried to give the title compound (4.7 g).

후처리

  1. filtrationthe resultant crystals were collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-733bf2d663034007ad71985e84407451
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562828B1

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