Phosphorus oxychloride → 2-Chloro-5-(3-methoxyphenyl)benzimidazole

HRID 413249노트

반응식

HRID 413249 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:18]=[CH:17][C:12]3[NH:13][C:14](=O)[NH:15][C:11]=3[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.P(Cl)(Cl)([Cl:21])=O>[Cl-].C[N+](C)(C)C>[Cl:21][C:14]1[NH:15][C:11]2[CH:10]=[C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=[CH:17][C:12]=2[N:13]=1

참가 물질

4

반응물 2

HCID 24813Phosphorus oxychlorideHCID 223253275-(3-Methoxyphenyl)benzimidazolidin-2-one

생성물 1

HCID 120716652-Chloro-5-(3-methoxyphenyl)benzimidazole

시약·촉매·용매 1

HCID 6379Tetramethylammonium chloride촉매

실험 절차

Heat a mixture of 5-(3-methoxyphenyl)benzimidazolidin-2-one (1.4 g) and tetramethylammonium chloride (ca. 2 g) in phosphorous oxychloride at 100° C. for 8 hours. After cooling, concentrate the mixture in vacuo, triturate with water, and neutralize with ammonium hydroxide. Collect the precipitate and air-dry to obtain 2-chloro-5-(3-methoxyphenyl)benzimidazole.

후처리

  1. temperatureHeat
  2. temperatureAfter cooling
  3. concentrationconcentrate the mixture in vacuo
  4. customtriturate with water
  5. customCollect the precipitate
  6. customair-dry

출처 및 근거

ORD 기록
ord-830417ba0abd4286956031aaf20311f9
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566367B2

반응 노트

불러오는 중…