Phosgene → 10-Methoxy-5H-dibenz(b,f)azepine-5-carbonyl chloride
반응식
C1C=CC2N(C(N)=O)C3C=CC=CC=3C(=O)CC=2C=1.[CH3:20][O:21][C:22]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[NH:26][C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[CH:23]=1.[C:37](Cl)([Cl:39])=[O:38]>>[CH3:20][O:21][C:22]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[N:26]([C:37]([Cl:39])=[O:38])[C:25]2[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=2[CH:23]=1참가 물질
4
실험 절차
U.S. Pat. No. 3,642,775 assigned to Ciba-Geigy Corporation, claims Oxcarbazepine specifically and discloses the process for the preparation of Oxcarbazepine, wherein 10-methoxy-5H-dibenz[b,f]azepine is reacted with phosgene gas to give 10-methoxy-5H-dibenz[b,f]azepine-5-carbonyl chloride and ammonolysis of the resultant compound to give the amide followed by hydrolysis to give Oxcarbazepine.
출처 및 근거
- ORD 기록
- ord-60bf5f9e5dc041ce8cc30181f4c613f9