Mandelic Acid → 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide

HRID 41346

반응식

HRID 41346 반응식
[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[O-:18][C:19]#[N:20].[Na+].C(O)(=O)C(C1C=CC=CC=1)O.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:19]([NH2:20])=[O:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1

참가 물질

6

반응물 4

HCID 1292Mandelic AcidHCID 14798Sodium HydroxideHCID 7842410-MethoxyiminostilbeneHCID 517096Sodium Cyanate

생성물 1

HCID 12003110-methoxy-5H-dibenz(b,f)azepine-5-carboxamide수율 83.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A suspension of 10 g of 10-methoxyiminostilbene in 200 ml toluene was treated with 20 g of sodium cyanate and 39 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 19 hrs. The resulting suspension was filtered, washed with water and dried to give 10 g of 10-methoxy carbamazepine.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for about 10 hrs
  3. temperaturemaintained for 19 hrs
  4. filtrationThe resulting suspension was filtered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-d481f292f5d5474a8f07a889c5a31c7f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530647B2

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