Hydrochloric Acid → Ethyl 5-methyl-2-phenylimidazole-4-acetate

HRID 413969노트

반응식

HRID 413969 반응식
Cl.[C:2]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])#N.[OH2:17].[OH-].[Na+].[CH2:20]([OH:22])[CH3:21]>>[CH2:20]([O:22][C:2]([CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][C:9]=1[CH3:10])=[O:17])[CH3:21]

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 14798Sodium HydroxideHCID 65475Mefenidil

생성물 1

HCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

실험 절차

Hydrochloric acid in ethanol (35%, 150 ml) was added to 4-cyanomethyl-5-methyl-2-phenylimidazole (20.5 g) and heated to reflux temperature. After 1 h the reaction mixture was poured into water (400 ml) and NaOH was added (pH>8), followed by extraction with dichloromethane (3 times). The combined organic layers were dried over sodium sulfate and evaporated to dryness in vacuo.

후처리

  1. temperatureheated
  2. temperatureto reflux temperature
  3. additionwas added (pH>8)
  4. extractionfollowed by extraction with dichloromethane (3 times)
  5. dry with materialThe combined organic layers were dried over sodium sulfate
  6. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-992370299d9d4e1298eeaed20b74f565
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569863B1

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