3-Bromo-2,6-dimethoxybenzoic acid → HCID 13493825, 화합물

HRID 414077

반응식

HRID 414077 반응식
[Br:1][C:2]1[C:3]([O:13][CH3:14])=[C:4]([C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[CH2:15]([N:18]1[CH2:22][CH2:21][CH2:20][CH:19]1[CH2:23][NH2:24])[CH2:16][CH3:17]>C(Cl)(Cl)Cl>[CH2:15]([N:18]1[CH2:22][CH2:21][CH2:20][CH:19]1[CH2:23][NH:24][C:5](=[O:7])[C:4]1[C:8]([O:11][CH3:12])=[CH:9][CH:10]=[C:2]([Br:1])[C:3]=1[O:13][CH3:14])[CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 27747443-Bromo-2,6-dimethoxybenzoic acidHCID 128290041-(1-Propylpyrrolidin-2-yl)methanamine

생성물 1

HCID 13493825HCID 13493825, 화합물수율 79%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The title compound was prepared from 3-bromo-2,6-dimethoxybenzoic acid via the acylchloride and (-)-1-n-propyl-2-(aminomethyl)pyrrolidine in the same manner as described in Example 8. Yield 79%. M.p. 103°-104° C. [α]D20 =-85.4° (c=0.5; CHCl3).

출처 및 근거

ORD 기록
ord-1248cf2a2c5c4dd19b1b4117c142eab7
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04789683

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