Phthalic Anhydride → Fluorescein phthalamic acid

HRID 414114

반응식

HRID 414114 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]2[C:8]([O:10][C:11]3([C:21]4[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:20]=4[O:19][C:13]4[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:12]3=4)[C:3]=2[CH:2]=1)=[O:9].[C:27]1(=[O:37])[O:32][C:30](=[O:31])[C:29]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:28]12>C(O)(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[C:3]([C:11]2[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=3[O:19][C:20]3[C:21]=2[CH:22]=[CH:23][C:24]([CH:25]=3)=[O:26])[CH:2]=1.[C:27]([OH:32])(=[O:37])[C:28]1[C:29](=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:30]([NH2:7])=[O:31]

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 768455-Aminofluorescein

생성물 1

HCID 131714783Fluorescein phthalamic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 350 mg (0.001 mol) of 5-aminofluorescein and 200 mg of phthalic anhydride in 5 milliliters of glacial acetic acid was stirred at ambient temperature for 48 hours. The yellow reddish product was filtered and washed once with acetic acid and twice with diethyl ether. 460 Mg of fluorescein-phthalamic acid was obtained. I.R (KBR) showed bands at 3060; 3000; 1685; 1590; 1540; 1480; 1430; 1350; 1310; 1270; 1230; 1195; 1150; and 1115 cm-1.

후처리

  1. filtrationThe yellow reddish product was filtered
  2. washwashed once with acetic acid and twice with diethyl ether

출처 및 근거

ORD 기록
ord-8802a0af17cc47a483ae12bd5ade6273
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04789742

연결된 노트

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