(3-Chloro-2-hydroxypropyl)trimethylammonium chloride → 2-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

HRID 414338

반응식

HRID 414338 반응식
[Na].[OH:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1.[Cl-].[Cl:19][CH2:20][CH:21]([OH:27])[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]>Cl.C(O)C>[Cl-:19].[OH:27][CH:21]([CH2:20][O:2][C:3]1[CH:16]=[CH:15][C:14]2[S:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:17])[C:5]=2[CH:4]=1)[CH2:22][N+:23]([CH3:26])([CH3:25])[CH3:24]

참가 물질

6

반응물 3

HCID 18732(3-Chloro-2-hydroxypropyl)trimethylammonium chlorideHCID 5360545SodiumHCID 97945682-Hydroxy-9H-thioxanthen-9-one

생성물 1

HCID 135936912-Hydroxy-3-(9-oxo-9H-thioxanthen-2-yloxy)-N,N,N-trimethyl-1-propanaminium chloride

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 702Ethanol용매

실험 절차

Sodium (1.36 g) was reacted with absolute ethanol (120 mls) and 2-hydroxy-thioxanthone (11.4 g) (prepared by a method analogous to that of H. Christopher and S. Smiles. J.C.S., 1911, 99, 2050-2051) was added. To the stirred refluxing mixture (3-chloro-2-hydroxypropyl)trimethyl ammonium chloride (10.7 g) was added and the mixture refluxed overnight. After adjusting the pH to ca. 4 via the addition of a few drops of 2N isopropanolic hydrogen chloride solution, hot filtration followed by ice bath cooling of the filtrate and filtration gave the crude title compound which was washed with methanol and vacuum dried.

후처리

  1. customprepared by a method analogous to that of H
  2. addition, 1911, 99, 2050-2051) was added
  3. additionwas added
  4. temperaturethe mixture refluxed overnight
  5. customfollowed by ice bath
  6. temperaturecooling of the filtrate and filtration

출처 및 근거

ORD 기록
ord-f353a8dbe8964c8b95120697baa968ca
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791213

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