Nitric Acid → 4-Methyl-6-nitro-7-hydroxy-1-indanone

HRID 414675

반응식

HRID 414675 반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].C(OC(=O)C)(=O)C.[N+:20]([O-])([OH:22])=[O:21]>C(O)(=O)C>[CH3:1][C:2]1[CH:10]=[C:9]([N+:20]([O-:22])=[O:21])[C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 124362447-Hydroxy-4-methyl-1-indanone

생성물 1

HCID 136041424-Methyl-6-nitro-7-hydroxy-1-indanone

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

Into a solution of 25.6 g of 4-methyl-7-hydroxy-1-indanone in 250 ml of acetic acid was added 19.4 ml of acetic anhydride and a solution of 15.4 ml of concentrated nitric acid in 50 ml of acetic acid gradually. The reaction mixture was concentrated to drynsss, and the residue was washed with ether to obtain 25.7 g of 4-methyl-6-nitro-7-hydroxy-1-indanone.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with ether

출처 및 근거

ORD 기록
ord-5cb9e452ae114983b72b93924d0f9940
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04792628

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