alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanol → HCID 14349136, 화합물

HRID 414843노트

반응식

HRID 414843 반응식
[H-].[Na+].[OH:3][CH:4]([C:10]1[CH:11]=[C:12]([CH:25]=[CH:26][CH:27]=1)[O:13][CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:28]I>C(OCC)C>[CH3:28][O:3][CH:4]([C:10]1[CH:11]=[C:12]([CH:25]=[CH:26][CH:27]=1)[O:13][CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

5

반응물 3

HCID 5059alpha-Pentyl-3-(2-quinolinylmethoxy)benzenemethanolHCID 6328Methyl iodideHCID 24758Sodium hydride

생성물 1

HCID 14349136HCID 14349136, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a suspension of sodium hydride (0.5 g) in ethyl ether at 0° C. is added 2-[3-(1-hydroxyhexyl)phenoxymethyl]quinoline (1.8 g) in ether. The mixture is allowed to warm to room temperature. Methyl iodide (0.6 ml) is added and the reaction is stirred at room temperature for three days. The reaction mixture is quenched with saturated aqueous ammonium chloride and extracted with ethyl ether. The organic extract is washed with water, dried (MgSO4) and concentrated to an oil, which is purified by HPLC on silica gel using a 1:9 ratio of ethyl acetate/hexane as an eluent.

후처리

  1. customThe reaction mixture is quenched with saturated aqueous ammonium chloride
  2. extractionextracted with ethyl ether
  3. extractionThe organic extract
  4. washis washed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated to an oil, which
  7. customis purified by HPLC on silica gel using a 1:9 ratio of ethyl acetate/hexane as an eluent

출처 및 근거

ORD 기록
ord-69016eb1462448a69dae68a1e73cf313
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04794188

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