Hydrochloric Acid → HCID 68817634, 화합물

HRID 41498

반응식

HRID 41498 반응식
CS(C)=O.[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 679Dimethyl Sulfoxide2회HCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

생성물 1

HCID 68817634HCID 68817634, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Dimethyl sulfoxide (1 mL) and hydrochloric acid (22 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (99.37 mg). Dimethyl sulfoxide (2 mL) was added to and dissolved in the mixture while heating the mixture, 2-propanol (3 mL) was added to the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (88.65 mg).

후처리

  1. dissolutiondissolved in the mixture
  2. additionwas added to the mixture
  3. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-d69699ced6d04373b7ba39101758b8fe
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530654B2

연결된 노트

불러오는 중…