Sodium hydride → Tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl) phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate

HRID 416061

반응식

HRID 416061 반응식
[Cl:1][C:2]1[C:18]([Cl:19])=[C:17]([CH2:20][CH2:21][CH:22]([OH:38])[C:23]2[S:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH:16]=[CH:15][C:3]=1[O:4][C:5]([CH3:14])([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[H-].[Na+].[I:41][C:42]1[CH:49]=[CH:48][C:45]([CH2:46]Br)=[CH:44][CH:43]=1>>[I:41][C:42]1[CH:49]=[CH:48][C:45]([CH2:46][O:38][CH:22]([C:23]2[S:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:35])([F:36])[F:37])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:3]([O:4][C:5]([CH3:13])([CH3:14])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])=[C:2]([Cl:1])[C:18]=2[Cl:19])=[CH:44][CH:43]=1

참가 물질

4

반응물 3

HCID 24758Sodium hydrideHCID 9542584-Iodobenzyl bromideHCID 25062865Tert-butyl 2-(2,3-dichloro-4-(3-hydroxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate

생성물 1

HCID 25062867Tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl) phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate

실험 절차

Tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate is prepared from tert-butyl 2-(2,3-dichloro-4-(3-hydroxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate using 1.1 equivalents of sodium hydride and 1.1 equivalents of 4-iodobenzyl bromide according to general procedure H.

출처 및 근거

ORD 기록
ord-8c65d6f7a55b463b87fa5e56217b0ff8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08088819B2

연결된 노트

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