3-Ethylpyridine → 3-Ethylpyridine

HRID 417795

반응식

HRID 417795 반응식
[CH2:1]([C:3]1[CH:4]=[CH:5][C:6](=O)[N:7](C2C=CC=CC=2)[CH:8]=1)[CH3:2].[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]>C(O)(=O)CCCCCCC/C=C\CCCCCCCC>[NH2:20][C:6]1[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][N:7]=1.[CH2:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:17]

참가 물질

5

반응물 2

HCID 108233-EthylpyridineHCID 101303775-ETHYL-1-PHENYL-1H-PYRIDIN-2-ONE

생성물 2

HCID 108233-EthylpyridineHCID 98127775-Ethylpyridin-2-amine

시약·촉매·용매 1

HCID 445639Oleic Acid촉매

실험 절차

In said first reaction scheme, we have found that 5-ethyl-1-phenyl-2-(1H)-pyridone can be made from 3-ethyl pyridine (available from Sigma-Aldrich Corporation, St. Louis, Mo.) which is reacted with NaNH2 in presence of a small amount of oleic acid as a catalyst to speed up the reaction. A general reaction scheme for obtaining 2-amino-5-ethyl pyridine isomer from 3-ethylpyridine is provided in U.S. Pat. No. 5,003,069 to McGill et al, “Chichibabin Reaction,” at Example 12. U.S. Pat. No. 5,003,069 is herein incorporated by reference as if fully set forth herein. In this reaction 3-ethyl pyridine (I) is converted to 2-amino-5-ethylpyridine (II) as well as 2-amino-3-ethylpyridine(III).

후처리

  1. customIn said first reaction scheme, we
  2. customthe reaction
  3. customA general reaction scheme

출처 및 근거

ORD 기록
ord-a91e2bdc326949c5965b6b68c6e11de4
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093210B2

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