Hydrochloric Acid → HCID 59627748, 화합물
반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[CH:8]=[C:9]([I:11])[CH:10]=1)=[O:4].[OH-].[Na+].Cl>CO>[I:11][C:9]1[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=[C:7]([C:12]2[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[CH:8]=1참가 물질
5
실험 절차
5-Iodo-4′-methyl-biphenyl-3-carboxylic acid methyl ester (280 mg, 0.8 mmol) was added to a mixture of methanol (4 mL) and 2M aqueous NaOH (2 mL). The mixture was stirred for 48 hours at room temperature, then neutralized by addition of 1M aqueous HCl. Solvent was removed under reduced pressure and the mixture was coevaporated twice with toluene to give crude 5-iodo-4′-methyl-biphenyl-3-carboxylic acid, which was used directly in the next step.
후처리
- customSolvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-20903571eb09456ea21cc1894cba1589
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08093275B2
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