2,5-Dimethyl-1H-indole → 4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride

HRID 418428

반응식

HRID 418428 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.[Cl:12][C:13]1[C:22]2[C:17](=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1>CN1C(=O)CCC1.Cl.O1CCOCC1>[ClH:12].[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:13]1[C:22]3[C:17](=[C:18]([C:23]([F:26])([F:24])[F:25])[CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15][CH:14]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2

참가 물질

6

반응물 2

HCID 709652,5-Dimethyl-1H-indoleHCID 902624-Chloro-8-(trifluoromethyl)quinoline

생성물 1

HCID 1317293454-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride수율 67%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 13387N-methyl-2-pyrrolidone용매HCID 312751,4-Dioxane용매

반응 조건

온도
140 °C

실험 절차

A mixture of 2,5-dimethylindole (765 mg) and 4-chloro-8-trifluoromethylquinoline (1.22 g) in NMP (1.5 ml) and 4M HCl in dioxane (0.2 ml) was heated at 140° C. for 1 h. After cooling the mixture was triturated with ether and filtered to give the sub-title compound (1.33 g) as a dark red solid.

후처리

  1. temperatureAfter cooling the mixture
  2. customwas triturated with ether
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-3d83c96dcd864fa89b3975550fedd3df
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08093278B2

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