Sodium Hydroxide → N-[2-[(4-Hydroxyphenyl)sulfonyl]ethyl]-2-propanamine hydrochloride

HRID 4213노트

반응식

HRID 4213 반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH2:12][CH2:13][NH:14][CH:15]([CH3:17])[CH3:16])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-:18].[Na+]>CS(C)=O>[ClH:2].[OH:18][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH2:12][CH2:13][NH:14][CH:15]([CH3:17])[CH3:16])(=[O:11])=[O:10])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13655033N-[2-(4-chlorophenylsulfonyl)ethyl]-2-propanamine hydrochloride

생성물 1

HCID 20152889N-[2-[(4-Hydroxyphenyl)sulfonyl]ethyl]-2-propanamine hydrochloride

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

A solution of N-[2-[(4-chlorophenyl)sulfonyl]ethyl]-1-methylethanamine hydrochloride and sodium hydroxide in 500 ml of dimethyl sulfoxide is heated at 95° C. for 2 hrs with stirring. The solvent is removed by rotary evaporation (vacuum pump) and the residue is partitioned between water (pH adjusted to 7 by the addition of dilute hydrochloric acid) and chloroform. The chloroform is removed and the residue is converted to the hydrochloride salt with ethereal hydrogen chloride. The salt is then recrystallized from methanol-diethyl ether to give crystalline title compound.

후처리

  1. customThe solvent is removed by rotary evaporation (vacuum pump)
  2. customthe residue is partitioned between water (
  3. additionpH adjusted to 7 by the addition of dilute hydrochloric acid) and chloroform
  4. customThe chloroform is removed
  5. customThe salt is then recrystallized from methanol-diethyl ether

출처 및 근거

ORD 기록
ord-53878bc16b5f4166be999b2b304deda7
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04724235

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