Methylhydrazine → Ethyl 2-(methylhydrazono)propanoate

HRID 421897

반응식

HRID 421897 반응식
[C:1]([O:6][CH2:7][CH3:8])(=[O:5])[C:2]([CH3:4])=O.[O-]S([O-])(=O)=O.[Mg+2].[CH3:15][NH:16][NH2:17]>C(Cl)(Cl)Cl>[CH3:15][NH:16][N:17]=[C:2]([CH3:4])[C:1]([O:6][CH2:7][CH3:8])=[O:5]

참가 물질

5

반응물 3

HCID 6061MethylhydrazineHCID 12041Ethyl pyruvateHCID 24083Sulfuric acid magnesium salt (1:1)

생성물 1

HCID 73828661Ethyl 2-(methylhydrazono)propanoate수율 94%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a suspension of ethyl pyruvate (37.8 mL, 338 mmol) and MgSO4 (40.8 g, 339 mmol) in CHCl3 (500 mL) was added a solution of methylhydrazine (18.0 mL, 332 mmol) in CHCl3 (100 mL) at 0° C. The reaction mixture was warmed to room temperature. After stirring for 24 hours at room temperature, the reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give 44 g (94%) of the desired product that was used directly without further purification.

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f1cbf88a550342928536cbe884acfa47
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101611B2

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