Hydrochloric Acid → 3-Chloro-2-cyanobenzoic acid

HRID 421994노트

반응식

HRID 421994 반응식
C[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]#[N:12])[C:3]=1[Cl:13].[OH-].[Na+].Cl>CO>[Cl:13][C:3]1[C:4]([C:11]#[N:12])=[C:5]([CH:9]=[CH:10][CH:2]=1)[C:6]([OH:8])=[O:7]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66676571Methyl 3-chloro-2-cyanobenzoic acid

생성물 1

HCID 533972953-Chloro-2-cyanobenzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The mixture of 430 mg of methyl 3-chloro-2-cyanobenzoic acid obtained by the same manner as in U.S. Pat. No. 4,900,739, 22 ml of methanol and 2.5 ml of aqueous sodium hydroxide (1 mol/l) was stirring at room temperature for 2 hours. To the reaction mixture was added hydrochloride (5 mol/l) and was extracted with chloroform. The organic layer was washed with water and saturated brine, and then dried over magnesium sulfate. The organic layer was filtered and concentrated in vacuo to give the title compound.

후처리

  1. customobtained by the same manner as in U.S
  2. extractionwas extracted with chloroform
  3. washThe organic layer was washed with water and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe organic layer was filtered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bdf338e722c146889b2ab6f5cf116b09
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101621B2

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