Hydrochloric Acid → 2-(3,4-Dichlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid

HRID 422041

반응식

HRID 422041 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][C:6]1[NH:15][C:14](=[O:16])[C:13]2[C:8](=[CH:9][C:10]([C:17]([O:19]C)=[O:18])=[CH:11][CH:12]=2)[N:7]=1.[OH-].[Na+].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][C:6]1[NH:15][C:14](=[O:16])[C:13]2[C:8](=[CH:9][C:10]([C:17]([OH:19])=[O:18])=[CH:11][CH:12]=2)[N:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 136330126Methyl 2-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

생성물 1

HCID 1359004542-(3,4-Dichlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylic acid수율 103%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 100 mg of methyl 2-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate which was synthesized in Production Example 2, 0.5 mL of 1N sodium hydroxide and 1 mL of water was heated under reflux for about 3 hours. After cooling off, 1N hydrochloric acid was added to the reaction solution to render the latter acidic, and the resulting precipitate was recovered by filtration and dried to provide 99 mg of the title compound.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for about 3 hours
  3. temperatureAfter cooling off
  4. filtrationwas recovered by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-50fe3afbf21c4a3a9400620cb6761b79
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101624B2

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