Hydrochloric Acid → 2-Amino-5-nitrobenzenethiol

HRID 424483

반응식

HRID 424483 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]2[N:8]=C[S:10][C:6]=2[CH:5]=1)([O-:3])=[O:2].O.NN.Cl>C(O)C.O>[NH2:8][C:7]1[CH:11]=[CH:12][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][C:6]=1[SH:10]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 24654Hydrazine hydrate (1:1)HCID 762566-Nitrobenzothiazole

생성물 1

HCID 109866912-Amino-5-nitrobenzenethiol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a stirred suspension of 6-nitrobenzo[d]thiazole (1.64 g, 9.10 mmol) in ethanol (16 mL) was added hydrazine hydrate (2.66 mL, 54.6 mmol). The resulting dark solution was stirred overnight at room temperature. The mixture was then diluted with water and slowly acidified with 3 M HCl, giving a yellow suspension. The mixture was then extracted with dichloromethane. The combined organics were dried, filtered, and concentrated, giving a yellow solid, used directly in the subsequent reaction. 1H NMR (DMSO-d6) δ 8.09 (brs, 1H), 7.87 (d, J=8.7 Hz, 1H), 6.74 (d, J=9.0 Hz, 1H), 6.27 (brs, 2H); MS-EI: (m/z, %) 170 (M+, 100), 140 (28), 124 (35).

후처리

  1. customgiving a yellow suspension
  2. extractionThe mixture was then extracted with dichloromethane
  3. customThe combined organics were dried
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customgiving a yellow solid
  7. customused directly in the subsequent reaction

출처 및 근거

ORD 기록
ord-6c5b3c41325c4c05a926a6970d2485b8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106043B2

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