2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol → alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-3-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

HRID 424911

반응식

HRID 424911 반응식
[C:1]1([N:7]2[C:11](=[O:12])[CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:17][C:18]([F:26])([F:25])[C:19](=[O:24])[C:20]([O:22][CH3:23])=[O:21]>C(Cl)(Cl)Cl>[CH3:23][O:22][C:20](=[O:21])[C:19]([OH:24])([C:18]([F:26])([F:25])[F:17])[C:10]1[C:11](=[O:12])[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[NH:8][C:9]=1[C:13]([F:15])([F:16])[F:14]

참가 물질

4

반응물 2

HCID 8927172-Phenyl-5-trifluoromethyl-2H-pyrazol-3-olHCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoate

생성물 1

HCID 86639740alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-3-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
80 °C

실험 절차

To a chloroform solution (5 ml) of 1-phenyl-3-trifluoromethyl-5-pyrazolone (114 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (172 mg).

후처리

  1. customAfter removing the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-27302a412d58438cace41fbc225521bf
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106086B2

연결된 노트

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