Methyl 3,3,3-trifluoro-2-oxopropanoate → 1-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

HRID 424914

반응식

HRID 424914 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH:11]=[C:10]([CH3:14])[NH:9]2)=[CH:4][CH:3]=1.[F:15][C:16]([F:24])([F:23])[C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19]>C(Cl)(Cl)Cl>[CH3:21][O:20][C:18](=[O:19])[C:17]([OH:22])([C:16]([F:24])([F:23])[F:15])[C:11]1[C:12](=[O:13])[N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[NH:9][C:10]=1[CH3:14]

참가 물질

4

반응물 2

HCID 2734931Methyl 3,3,3-trifluoro-2-oxopropanoateHCID 34428742-(4-Chlorophenyl)-5-methyl-1H-pyrazol-3(2H)-one

생성물 1

HCID 441398191-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
80 °C

실험 절차

To a chloroform solution (5 ml) of 1-(4-chlorophenyl)-3-methyl-5-pyrazolone (104 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (182 mg).

후처리

  1. customAfter removing the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-e79a7b146dc941908744a9ae7843889e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106086B2

연결된 노트

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