Dimethylformamide → N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide

HRID 425121

반응식

HRID 425121 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[CH3:12][N:13]([CH:15]=O)[CH3:14].COC(OC)N(C)C.S([O-])(O)(=O)=O.[Na+]>O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](/[N:11]=[CH:12]/[N:13]([CH3:15])[CH3:14])(=[O:10])=[O:9]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 78373Dimethylformamide dimethyl acetalHCID 516919Sodium BisulfateHCID 28012632-Bromobenzenesulfonamide2회

생성물 1

HCID 11779014N'-(2-bromophenyl)sulfonyl-N,N-dimethylmethanimidamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The starting material, 2-bromobenzene-1-sulfonamide, is commercially available. Reaction of 2-bromobenzene-1-sulfonamide in a solvent such as DMF, with 1,1-dimethoxy-N,N-dimethylmethanamine, followed by the addition of sodium hydrogen sulfate in water, yields 2-bromo-N-[1-dimethylaminometh-(E)-ylidene]benzene-sulfonamide. This compound is reacted with 4-methylphenylboronic acid to yield 4′-methylbiphenyl-2-sulfonic acid 1-dimethylaminometh-(E)-ylideneamide, then the —(CH2)r-L moiety is added, for example, by a halogenation reaction, to form compound (1c).

출처 및 근거

ORD 기록
ord-0e40447194914754a69e1071fc4b0167
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106082B2

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